000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Stockholders' Equity (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 995551 - Disclosure - Note 1 - Organization and Nature of Business link:calculationLink link:definitionLink link:presentationLink 995552 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 995553 - Disclosure - Note 3 - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 995554 - Disclosure - Note 4 - Balance Sheet Components link:calculationLink link:definitionLink link:presentationLink 995555 - Disclosure - Note 5 - Revenue link:calculationLink link:definitionLink link:presentationLink 995556 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties link:calculationLink link:definitionLink link:presentationLink 995557 - Disclosure - Note 7 - Leases link:calculationLink link:definitionLink link:presentationLink 995558 - Disclosure - Note 8 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 995559 - Disclosure - Note 9 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 995560 - Disclosure - Note 10 - Equity Incentive Plans link:calculationLink link:definitionLink link:presentationLink 995561 - Disclosure - Note 11 - Benefit Plan link:calculationLink link:definitionLink link:presentationLink 995562 - Disclosure - Note 12 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 995563 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders link:calculationLink link:definitionLink link:presentationLink 995564 - Disclosure - Note 14 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 995565 - Disclosure - Note 15 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 995567 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995568 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 995569 - Disclosure - Note 3 - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 995570 - Disclosure - Note 4 - Balance Sheet Components (Tables) link:calculationLink link:definitionLink link:presentationLink 995571 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Tables) link:calculationLink link:definitionLink link:presentationLink 995572 - Disclosure - Note 7 - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 995573 - Disclosure - Note 9 - Stockholders' Equity (Tables) link:calculationLink link:definitionLink link:presentationLink 995574 - Disclosure - Note 10 - Equity Incentive Plans (Tables) link:calculationLink link:definitionLink link:presentationLink 995575 - Disclosure - Note 12 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 995576 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders (Tables) link:calculationLink link:definitionLink link:presentationLink 995577 - Disclosure - Note 14 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 995578 - Disclosure - Note 1 - Organization and Nature of Business (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995579 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995580 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Estimated Useful Lives (Details) link:calculationLink link:definitionLink link:presentationLink 995581 - Disclosure - Note 3 - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995582 - Disclosure - Note 3 - Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 995583 - Disclosure - Note 4 - Balance Sheet Components (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995584 - Disclosure - Note 4 - Balance Sheet Components - Cash and Cash Equivalents and Investments (Details) link:calculationLink link:definitionLink link:presentationLink 995585 - Disclosure - Note 4 - Balance Sheet Components - Prepaid Expenses and Other Current Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995586 - Disclosure - Note 4 - Balance Sheet Components - Property and Equipment, Net (Details) link:calculationLink link:definitionLink link:presentationLink 995587 - Disclosure - Note 4 - Balance Sheet Components - Intangible Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995588 - Disclosure - Note 4 - Balance Sheet Components - Estimated Future Amortization Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995589 - Disclosure - Note 4 - Balance Sheet Components - Deferred Revenue, by Arrangement, Disclosure (Details) link:calculationLink link:definitionLink link:presentationLink 995590 - Disclosure - Note 4 - Balance Sheet Components - Accrued Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995591 - Disclosure - Note 5 - Revenue (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995592 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995593 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties - Deferred Revenue Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995594 - Disclosure - Note 7 - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995595 - Disclosure - Note 7 - Leases - Lease Liabilities Payment Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 995596 - Disclosure - Note 7 - Leases - Operating Lease Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 995597 - Disclosure - Note 8 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995598 - Disclosure - Note 9 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995599 - Disclosure - Note 9 - Stockholders' Equity - Shares of Common Stock Reserved for Issuance (Details) link:calculationLink link:definitionLink link:presentationLink 995600 - Disclosure - Note 9 - Stockholders' Equity - Summary of Warrants Outstanding (Details) link:calculationLink link:definitionLink link:presentationLink 995601 - Disclosure - Note 10 - Equity Incentive Plans (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995602 - Disclosure - Note 10 - Equity Incentive Plans - Summary of Stock Option Transactions (Details) link:calculationLink link:definitionLink link:presentationLink 995603 - Disclosure - Note 10 - Equity Incentive Plans - Assumptions of Options (Details) link:calculationLink link:definitionLink link:presentationLink 995604 - Disclosure - Note 10 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options (Details) link:calculationLink link:definitionLink link:presentationLink 995605 - Disclosure - Note 11 - Benefit Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995606 - Disclosure - Note 12 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995607 - Disclosure - Note 12 - Income Taxes - Components of Income Tax Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995608 - Disclosure - Note 12 - Income Taxes - Components of Deferred Tax Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995609 - Disclosure - Note 12 - Income Taxes - Reconciliation of Effective Tax Rate (Details) link:calculationLink link:definitionLink link:presentationLink 995610 - Disclosure - Note 12 - Income Taxes - Unrecognized Tax Benefits (Details) link:calculationLink link:definitionLink link:presentationLink 995611 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net (Loss) Income Per Share (Details) link:calculationLink link:definitionLink link:presentationLink 995612 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995613 - Disclosure - Note 14 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995614 - Disclosure - Note 14 - Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details) link:calculationLink link:definitionLink link:presentationLink 995615 - Disclosure - Note 15 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink